N,N-Dimethyl-3-(1-naphthyloxy)-3-(2-thienyl)propan-1-amine
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چکیده
منابع مشابه
N,N-Dimethyl-3-(1-naphthyloxy)-3-(2-thienyl)propan-1-amine
The title compound, C(19)H(21)NOS, is an inter-mediate for the synthesis of duloxetine hydro-chloride. In the mol-ecular structure, the thio-phene and naphthalene ring systems make a dihedral angle of 87.5°. All bond lengths and angles involving heteroatoms are as expected. In the crystal structure, no classical hydrogen bonds are found.
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In the title compound, C(27)H(24)N(2)O(3), the five-membered pyrroldine ring adopts an envelope conformation (with the N atom in the flap position) and the six-membered pyran-one ring of the coumarine ring system adopts a slightly distorted boat conformation. The oxindole unit makes dihedral angles of 89.7 (1) and 25.6 (1)°, respectively, with the pyrrolidine ring and the coumarin ring system. ...
متن کاملUltrasound irradiation promoted enzymatic transesterification of (R/S)-1-chloro-3-(1-naphthyloxy)-2-propanol.
(R)-1-Chloro-3-(1-naphthyloxy)-2-propanol, which is the key intermediate of (S)-propranolol, was successfully prepared via enantioselective transesterification catalyzed by lipase under ultrasound irradiation. Compared with conventional shaking, the enzyme activity and enantioselectivity were dramatically increased under ultrasound exposure. Effects of various reaction conditions on the synthet...
متن کامل(2E)-1-(2,5-Dimethyl-3-thienyl)-3-(2-methoxyphenyl)prop-2-en-1-one
In the title compound, C(16)H(16)O(2)S, the central propenone group is almost planar (r.m.s. deviation = 0.009 Å) and subtends dihedral angles of 8.55 (8) and 16.22 (8)° to the 2-meth-oxy-phenyl and 2,5-dimethyl-thio-phene residues, respectively. The dihedral angle between the ring systems is 23.47 (5)°. In the crystal, mol-ecules are linked by weak C-H⋯π inter-actions and aromatic π-π stacking...
متن کامل(E)-1-(2,5-Dimethyl-3-thienyl)-3-(2-hydroxyphenyl)prop-2-en-1-one
In the title compound, C(15)H(14)O(2)S, the dihedral angle between the aromatic rings is 8.46 -(8)°. The central enone group is planar (r.m.s. deviation = 0.0267 Å) and is oriented at a dihedral angle of 1.20 (9)° with respect to the benzene ring and at 8.27 (9)° with respect to the thio-phene group. In the crystal, the mol-ecules are linked into polymeric chains extending along the b axis due ...
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ژورنال
عنوان ژورنال: Acta Crystallographica Section E Structure Reports Online
سال: 2008
ISSN: 1600-5368
DOI: 10.1107/s1600536808003255